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K pneumoniae has been implicated as a common cause of infection in the human body. Chew KL, Lin RT, Teo JW. 2005;58(9):894901. government site. 2010;54(1):17783. FEMS Immunol Med Microbiol. Xu H, Huo C, Sun Y, Zhou Y, Xiong Y, Zhao Z, Zhou Q, Sha L, Zhang B, Chen Y. Accessibility Klebsiella pneumoniae: the classical and other subtypes. WebUrinary tract infection and pneumonia are common diseases caused by Klebsiella pneumoniae.In rare circumstances, Klebsiella pneumoniae has been associated with abscess formation, thrombosis, septic emboli, and infective endocarditis. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. Clin Infect Dis. Lemierre's Syndrome Caused by Klebsiella pneumoniae in a Diabetic Patient: A Case Report and Review of the Literature. Hearing loss and seizures are the most frequent sequelae, with neurocognitive dysfunction as a less life-threatening possibility [27,28,29]. Clinical and molecular characteristics of multi-clone carbapenem-resistant hypervirulent (hypermucoviscous) Klebsiella pneumoniae isolates in a tertiary hospital in Beijing, China. Microorganisms. CYE, TS, SL and YW contributed equally in the preparation and reviewing of the manuscript. KLEBSIELLA INFECTION The report showed one 0.4-cm nodular enhancement in the left higher frontal lobe, without an increase in the diffusion-weighted image; microabscess was thus suspected (Fig. The increasing trends in the isolation rate of K. pneumoniae is of much concern. Trends in the frequency of multiple drug-resistant Enterobacteriaceae and their susceptibility to ertapenem, imipenem, and other antimicrobial agents: data from the Study for Monitoring Antimicrobial Resistance Trends 2002 to 2007. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Durand ML, Calderwood SB, Weber DJ, Miller SI, Southwick FS, Caviness VS Jr, Swartz MN. Acute bacterial meningitis in adults. Google Scholar. Part of To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Infect Dis Clin North Am. The patient was preliminarily diagnosed with a primary liver abscess and meningitis. Klebsiella pneumoniae can be broadly classified into two subtypes; classical Klebsiella pneumoniae (cKp) and non-classical Klebsiella pneumoniae (ncKp). Meng X, Yang J, Duan J, Liu S, Huang X, Wen X, Huang X, Fu C, Li J, Dou Q, Liu Y. Assessing molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae (CR-KP) with MLST and MALDI-TOF in Central China. Rollin G, Rossi B, Brisse S, Decr D, Leflon-Guibout V, Bert F, Hoffmann I, Decousser JW, Fantin B, Lefort A. Spontaneous and postsurgical/traumatic Klebsiella pneumoniae meningitis: two distinct clinico-microbiological entities. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022106s014lbl.pdf. CT angiography of the cerebral arteries showed cerebrovascular atherosclerosis without obvious vessel occlusion or thrombosis. Exhaustive search was conducted using PubMed, Web of Science, and Google scholar for most studies addressing the prevalence, risk factors, drug resistant-mediated genes and/or virulent factors of K. pneumoniae in Asia. 1995 May;94(5):2327. Wang JH, Liu YC, Lee SS, Yen MY, Chen YS, Wang JH, Wann SR, Lin HH. MeSH Identification and Characterization 7 of NDM-1-producing hypervirulent (hypermucoviscous) Klebsiella pneumoniae in China. Lancet Infect Dis. A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications. According to the multicenter cohort study of 1071 patients CSF was submitted for Gram staining and bacterial culture. Purpose To demonstrate the feasibility of continuous infusion of meropenemvaborbactam to optimize the treatment of carbapenem-resistant Enterobacterales. But if K. pneumoniae gets into other areas of [15], it was reported that, Chinese people had a colonization rate of 66.0% compared to Malay (14.3%), Indian (7.9%) and others nationals (11.8%). 2000 Sep;14(3):54763. Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. 1999;29:157071. Unable to load your collection due to an error, Unable to load your delegates due to an error. Klebsiella Pneumonia Escherichia coli and K. pneumoniae are frequently identified as pathogens [5], but a series of cases in the United States showed that the Streptococcus milleri group was the most commonly found pathogen [6, 7]. Comparison of pyogenic liver abscess caused by non-klebsiella pneumoniae and Klebsiella pneumoniae. This will guide doctors in prescribing the proper antimicrobials in case of resistance gene evolution. Antimicrob Agents Chemother. Russo TA, Olson R, MacDonald U, Metzger D, Maltese LM, Drake EJ, Gulick AM. In fact, Klebsiellae account for up to 8% of all hospital-acquired infections. Please contact GARD if you need help finding additional information or resources on rare diseases, including clinical studies. van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M. Clinical features and prognostic factors in adults with bacterial meningitis. Since then, nearly a dozen people have died after contracting the bacteria strain. vii. The K. pneumoniae genotype K1 is an emerging pathogen capable of causing catastrophic septic ocular or CNS complications [16]. Owing to his severely impaired consciousness and critical illness, he received endotracheal intubation and was admitted to the intensive care unit for further medical treatment. J Clin Epidemiol. CHINET 2013 surveillance of bacterial resistance in China. Infect Drug Resist. In one study cited, primary liver abscess was defined as a liver abscess caused by Klebsiella pneumoniae occurring in the absence of any predisposing factors such as hepatobiliary disease, colorectal disease, or a history of intraabdominal surgery or trauma [16]. Proc Natl Acad Sci. In the United States, Klebsiella pneumoniae and Klebsiella oxytoca are the two strains responsible for most human illnesses. While it is more common among people of Asian descent, it has been increasingly reported globally among people of other ethnicities as well. Summary When bacteria called Klebsiella pneumoniae spread from the intestines and feces, they cause a range of infection types and tend to be antibiotic resistant. PubMed Several studies have reported mortality rates ranging from 5 to 40%, with the highest rates observed in patients with sepsis or meningitis [1]. Klebsiella pneumoniae-induced multiple invasive abscesses Klebsiella pneumoniae : an increasing threat to public health Antibiotic use and the risk of carbapenem-resistant extended-spectrum--lactamase-producing Klebsiella pneumoniae infection in hospitalized patients: results of a double casecontrol study. Klebsiella pneumoniae is a gram-negative, encapsulated, non-motile bacterium found in the environment and has been associated with pneumonia in patient populations with alcohol use disorder or diabetes mellitus. These infections could include: urinary tract infections; pneumonia; bloodstream infections (also called sepsis); The K. pneumoniae infections have considerably contributed to morbidity and mortality in patients with protracted ailments. Int J Infect Dis. Your patient is a 69-year-old man hospitalized with Klebsiella pneumoniae carbapenemase-producing (KPC-Kp) infection. Clin Gastroenterol Hepatol. Global and regional risk of disabling sequelae from bacterial meningitis: a systematic review and meta-analysis. The search filtered articles among the years of 2005 to 2019. Data extracted for meta-analysis were analyzed using comprehensive meta-analysis version 3. 2018;73(8):203946. Klebsiella pneumoniae is a Gram-negative, rod-shaped bacillus from the genus Klebsiella and family Enterobacteriaceae ( Boone et al., 2001 ). According to Shiri et al. 1972;300(7779):66871. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Lee SS, Chen YS, Tsai HC, Wann SR, Lin HH, Huang CK, Liu YC. Ampicillin and amoxicillin use and the risk of Klebsiella pneumoniae liver abscess in Taiwan. J Formos Med Assoc. Despite there is limited evidence on the efficacy of doripenem for treating meningitis, it is a broad-spectrum antibiotic that has demonstrated effectiveness against various bacterial infections [22], and has been approved for the treatment of complicated intra-abdominal infections [23]. Springer Nature. 1998;11(4):589603. 2012;45(2):1139. METHODS: Samples were collected at the Laboratory of Microbiology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia. Gu DX, Huang YL, Ma JH, Zhou HW, Fang Y, Cai JC, Hu YY, Zhang R. Detection of colistin resistance gene mcr-1 in hypervirulent Klebsiella pneumoniae and Escherichia coli isolates from an infant with diarrhea in China. Clin Microbiol Rev. 1998 Aug;17(8):55660. 2017;41(3):25275. infection Klebsiella pneumoniae 2005;40(9):133341. Currently GARD aims to provide the following information for this disease: This section is currently in development. In China, the most dominant MDR KPC-producing clone is the ST11. Martin RM, Bachman MA. Virginia Mason Medical Center said in the statement it is "difficult to determine whether Klebsiella pneumoniae caused or contributed" to the deaths since some patients' conditions were complex. Our Information Specialists are available to you by phone or by filling out our contact form. Provided by the Springer Nature SharedIt content-sharing initiative. Provided by the Springer Nature SharedIt content-sharing initiative. 2021 Jun 22;20(1):46. doi: 10.1186/s12941-021-00453-8. 2002 Dec;95(12):797802. Sci Rep. 2019;9(1):2271. The optimal treatment for K. pneumoniae invasive syndrome depends on the specific infection site and severity of the disease. Lancet. Due to the following reasons, some studies were excluded from this studies; articles not following CLSI recommended drug susceptibility testing methods, case reports, meta analyses or systematic reviews, letters to editor, review articles, non-English, and duplicate publication. 2 more deaths confirmed in bacterial outbreak at Virginia Mason The patient underwent a lumbar puncture to rule out meningitis. Pathology Shin SU, Park CM, Lee Y, Kim EC, Kim SJ, Goo JM. K. pneumoniae is an extremely rare cause of bacterial meningitis. It has been shown that fimbriae contribute to diseases of the urinary tract [34], mediates the development of biofilms and also it is involve in the adherence of the organism to medical devices. The purpose of this study was to identify the antibiotic resistance pattern and biofilm-producing capacity of K. If material is not included in the articles Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Klebsiella pneumonia, also known as Friedlnder pneumonia , refers to pneumonia resulting from an infection from the organism Klebsiella pneumoniae . Infect Immun. Careers. Written informed consent was obtained from the patient for publication of this case report and any accompanying images. Klebsiella [klebseeelluh] is a type of gram-negative bacteria that can cause different types of healthcare-associated infections, including pneumonia, Patients with primary sclerosing cholangitis (PSC) harboring Klebsiella pneumoniae (Kp) exhibit poor clinical outcomes. Talk to a trusted doctor before choosing to participate in any clinical study. Comparison of prevalence of virulence factors for Klebsiella pneumoniae liver abscesses between isolates with capsular K1/K2 and non-K1/K2 serotypes. Kaplan GG, Gregson DB, Laupland KB. The score on the Glasgow Coma Scale was 6 (E1M4V1, with lower scores indicating greater alteration of consciousness). The most virulent factors utilized by K. pneumoniae are; hypermucoviscous phenotype and mucoviscosity-related genes, genes for biosynthesis of lipopolysaccharide, iron uptake and transport genes and finally, adhesive genes. In humans, the bacteria are often present in parts of the digestive tract where they do not generally cause problems. Characterize carbapenem-resistant Klebsiella pneumoniae isolates for nosocomial pneumonia and their Gram-negative bacteria neighbors in the respiratory tract. Lin YT, Liu CJ, Yeh YC, Chen TJ, Fung CP. In this review, although there is an increasing trend in the isolation rate, their resistance rates were not in tandem as this was evident in the decreasing trends over the years. 1). Different resistance-mediated genes mediate antimicrobial drug resistance in K. pneumoniae. Risk factors for acquisition of carbapenem resistant Enterobacteriaceae in an acute tertiary care hospital in Singapore. 2020 Oct;13(5):927-934. doi: 10.1007/s12328-020-01161-0. The infection is potentially serious. The production of ESBLs is one of the resistance mechanisms in Enterobacteriaceae, and they are increasingly detected in Escherichia coli and Klebsiella pneumoniae globally. On presentation, his initial vital signs included a body temperature of 39.4C, heart rate of 118 beats per minute, respiratory rate of 22 breaths per minute, blood pressure of 88/53 mmHg, and oxygen saturation of 96% on ambient air. He was successfully extubated and transferred to a general ward on the 10th day. Klebsiella pneumoniae can cause different types of health care-associated infections, including pneumonia, bloodstream infections, wound or surgical site infections, and meningitis, the CDC states. Aerobactin, but not yersiniabactin, salmochelin, or enterobactin, enables the growth/survival of hypervirulent (hypermucoviscous) Klebsiella pneumoniae ex vivo and in vivo. Clinical and radiological features of invasive Klebsiella pneumoniae liver abscess syndrome. Zhao D, Zuo Y, Wang Z, Li J. Antimicrob Agents Chemother. 2019;39(2):16775. Klebsiella pneumoniae is a Gram-negative, rod-shaped bacillus from the genus Klebsiella and family Enterobacteriaceae ( Boone et al., 2001 ). Further work-up revealed bilateral renal vein thrombosis, inferior vena cava thrombosis, septic emboli, and perirenal abscess. Liu Z, Gu Y, Li X, Liu Y, Ye Y, Guan S, Li J. Am J Gastroenterol. According to Fang et al. Emerg Infect Dis 2008 Oct;14(10):1592600. Russo TA, Olson R, MacDonald U, Beanan J, Davidson BA. Saleem AF, Qamar FN, Shahzad H, Qadir M, Zaidi AK. 2012 Nov;12(11):8817. Please enable it to take advantage of the complete set of features! In humans, the bacteria are often present in parts of the digestive tract where they do not generally cause problems. BMC Microbiol. PubMed Central Cookies policy. The increase in colonization rate of K. pneumoniae as observed in these clinical samples is of epidemiological important because, Klebsiella nosocomial infection was four times higher in stool carriers compared with non-carriers [19]. Hypermucoviscous Klebsiella pneumoniae: A Hypervirulent Strain College of Public Health, Zhengzhou University, Zhengzhou, 450001, China, General ICU, The First Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Critical Care Medicine, Zhengzhou, 450052, China, You can also search for this author in Semin Perinatol. A population-based study of pyogenic liver abscesses in the United States: incidence, mortality, and temporal trends. Web1 Introduction. Google Scholar. Prostatic abscess of Klebsiellapneumonia complicating septic pulmonary emboli and meningitis: A case report and brief review. Terms and Conditions, Beginning in October 2022, hospital staff at Virginia Mason Medical Center said it detected an increase in cases ofKlebsiella pneumoniaebacteria at itsdowntown campus. Resource(s) for Medical Professionals and Scientists on This Disease: This information is currently in development. PLoS ONE. Cookies policy. It also causes necrotizing pneumonia, pyogenic liver abscesses and endogenous endophthalmitis [3]. Phenotypic and molecular characterization of ESBL producing Ahmed M, Alam J, Hussain S, Aslam M. Prospective randomized comparative study of percutaneous catheter drainage and percutaneous needle aspiration in the treatment of liver abscess. Antimicrob Agents Chemother. Falagas ME, Kasiakou SK, Saravolatz LD. A brain magnetic resonance imaging scan with contrast was performed after extubation. Diabetes mellitus or impaired fasting glucose is the major observed risk factor for K. pneumoniae primary liver abscess; these conditions are not major risk factors for liver abscesses caused by organisms other than Klebsiella [1, 20]. https://doi.org/10.1186/s12941-019-0343-8, DOI: https://doi.org/10.1186/s12941-019-0343-8. Klebsiella pneumoniae invasive syndrome with liver abscess and purulent meningitis presenting as acute hemiplegia: a case report. Klebsiella pneumoniae: an increasing threat to public health. Before QJM. a The isolation rate of K. pneumoniae in China (Data extracted from CHINET surveillance system 2015 which collected data from outpatients and inpatients in 19 big hospitals from 14 provinces. These usually develop in hospital settings. 1993 Jan;7(1):218. Klebsiella Pneumoniae: A Cause of Hospital Infections - Verywell Prognosis can be improved by early instigation of both antibiotic and steroid treatments [33]. Klebsiella pneumoniae Carrier levels in hospitalized patients are significantly higher, with reported rates of 77% in the stool, 19% in the pharynx, and 42% on the hands [3]. Schiess N, Groce NE, Dua T. The Impact and Burden of Neurological Sequelae Following Bacterial Meningitis: A Narrative Review. 1998 Jun;26(6):14348. Klebsiella pneumoniae bacterial outbreak at Seattle hospital: 9 The original published articles on the prevalence of drug resistant strains of K. pneumoniae from hospital-acquired infections in some selected countries in Asia were considered. N Engl J Med. The reported mortality rate of K. pneumoniae BSIs varies from 15 to 79% [ 1, 2, 3, 4 ], which was lower than that of Acinetobacter baumannii BSIs (30 to 84%) [ 5, 6] but higher than Escherichia coli (5 to 2015;83(8):332533. GARD does not currently have information about the cause of this condition. Nosocomial Klebsiella infections: intestinal colonization as a reservoir. 2015;4(1):26. 2021 Mar;91(3):E86E90. CSF analysis revealed a WBC count of 4141 cells/L, with 87% neutrophils and 3% lymphocytes, protein level of 414mg/dL, and glucose level of 59mg/dL. Mansury D, Motamedifar M, Sarvari J, Shirazi B, Khaledi A. Primary liver abscess due to Klebsiella pneumoniae in Taiwan. FEMS Microbiol Rev. Ciprofloxacin treatment for cryptogenic Klebsiella pneumoniae liver abscesses. Klebsiella This strain was first identified in Eastern part of Asia and has since spread worldwide [6]. 4, Renai Rd., Daan Dist., Taipei City 106, Taipei, Taiwan, Yu Chang,Jiann-Hwa Chen,Wei-Lung Chen&Jui-Yuan Chung, School of Medicine, Fu Jen Catholic University, Taipei, Taiwan, School of Medicine, National Tsing Hua University, Hsinchu, Taiwan, You can also search for this author in From Table2, it can be seen that K. pneumoniae has a great resistance rate to most of the commonly used antimicrobials. PubMedGoogle Scholar. wound infections. Thornton A, Lee P. Publication bias in meta-analysis: its causes and consequences. statement and Google Scholar. Phenotypic and molecular characterization of ESBL producing 2010;66(1):7886. The pupils were 2.5mm, symmetrical, and reactive to light. It has been a known human pathogen since it was first isolated in the late nineteenth century by Edwin Klebs. PubMed Pollack M, Nieman R, Reinhardt J, Charache P, Jett M, Hardy JRP. The production of ESBLs is one of the resistance mechanisms in Enterobacteriaceae, and they are increasingly detected in Escherichia coli and Klebsiella pneumoniae globally. 2000;53(2):20716. Patient organizations can help patients and families connect. K. pneumoniae is facultatively anaerobic, oxidase-negative, and produces acid and gas from lactose. Antimicrobial resistance of hypervirulent Klebsiella pneumoniae: epidemiology, hypervirulence-associated determinants, and resistance mechanisms. In humans, the bacteria are often present in parts of the digestive tract where they do not generally cause problems. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. No acid-fast bacilli were observed on a mycobacterial smear, and no fungi were seen on examination of a fungal wet preparation. Arch Intern Med. Lancet 2021 Sep 25;398(10306):117183. Keywords: Jundishapur J Microbiol. It can cause lung abscesses and lead to severe bloodstream infections. 2017;21(7):483. A common destructive complication is pyogenic liver abscess that can be complicated by metastatic endophthalmitis as well as the involvement of the central nervous system, causing purulent meningitis or brain abscess. Klebsiella infection WebKlebsiella pneumoniae is a Gram-negative, non-motile, encapsulated, lactose - fermenting, facultative anaerobic, rod-shaped bacterium. Klebsiella pneumoniae Pyogenic liver abscess as endemic disease, Taiwan. Clin Infect Dis. Many collaborate with medical experts and researchers.Services of patient organizations differ, but may include: Clinical studies are part of clinical research and at the heart of all medical advances, including rare diseases. Yu WL, Ko WC, Cheng KC, Lee CC, Lai CC, Chuang YC. Kritsotakis EI, Tsioutis C, Roumbelaki M, Christidou A, Gikas A. K pneumoniae has been implicated as a common cause of infection in the human body. J Antimicrob Chemother. Jui-Yuan Chung. Klebsiella pneumoniae liver abscess associated with septic endophthalmitis. In this study was aimed to determine resistance of K. pneumoniae screened Paczosa MK, Mecsas J. Klebsiella pneumoniae: going on the offense with a strong defense. Andrade LN, Vitali L, Gaspar GG, Bellissimo-Rodrigues F, Martinez R, Darini AL. This has led to the emergences of strains such as hypervirulent Klebsiella pneumoniae (hvKp) or hypermucoviscous Klebsiella pneumoniae (HMKP). 2017;12(7):515. Dong N, Zhang R, Liu L, Li R, Lin D, Chan EW, Chen S. Genome analysis of clinical multilocus sequence Type 11 Klebsiella pneumoniae from China. A meta-analysis showed that the prevalence of K. pneumoniae infection has been increasing since the late 1980s and that it is now the main cause of liver abscess in Taiwan, accounting for almost 80% of cases [9]. Susceptibility of Klebsiella Pneumoniae Isolated from Pus The high prevalence rate of MDR and XDR K. pneumoniae subtypes reflects a multifactorial dissemination processes that include but not limited to: the spread of high risk global multi-resistant genetic lineage [11]; acquisition of successful multi-resistant plasmids; and acquisition of resistant genes located on successful transposons. WebUrinary tract infection and pneumonia are common diseases caused by Klebsiella pneumoniae.In rare circumstances, Klebsiella pneumoniae has been associated with [14], had reported the first outbreak of CR-HMKP strains which harbored blaNDM-1 gene, shared the same pulsotypes (PT) and belong to the same Sequence types (ST). McHardy JA, Selvaganeshapillai V, Khanna P, Whittington AM, Turton J, Gopal Rao G. Ann Clin Microbiol Antimicrob. BMC Infect Dis 23, 397 (2023). After secondary full text evaluation, 20 studies or articles (Table1) addressing the prevalence, drug resistant-mediated genes and/or virulent factors in K. pneumoniae in Asia were selected for the final meta-analysis. Klebsiella pneumoniae can infect a variety of sites, with the risk of infection being higher in the immunocompromised state such as diabetes mellitus. Find resources for patients and caregivers that address the challenges of living with a rare disease. Raritan, NJ: Janssen Pharmaceuticals, Inc. ; 2014. Epub 2020 Jul 7. There are a number of virulence factors that Antimicrobial Resist Infect Control. Hypermucoviscous Klebsiella pneumoniae (HvKP) is a hypervirulent strain of Klebsiella that causes metastatic spread and life-threatening infection. WebGeneral Information. 2). Fupin HU, Zhu D, Wang F, Jiang X, Sun Z, Chen Z, Zhidong HU, Jin LI, Xie Y, Kang M, Yingchun XU. Google Scholar. AI can help doctors with breast cancer risk predictions, Your California Privacy Rights / Privacy Policy. Draft genome sequences of three hypervirulent carbapenem-resistant Klebsiella pneumoniae isolates from bacteremia. Terrin N, Schmid CH, Lau J. For instance, patients with K. pneumoniae liver abscess may present with fever, abdominal pain, and jaundice, while those with pneumonia may present with cough, dyspnea, and chest pain. Fang CT, Lai SY, Yi WC, Hsueh PR, Liu KL, Chang SC. Liu SW, Chang HJ, Chia JH, Kuo AJ, Wu TL, Lee MH. 2018;24(7):10025. 2016;4(6):e01081116. Biofilm The higher rates of colonization are primarily related to the increasing use of antibiotics [3, 17, 18]. These include at least (a) surface antigen, particularly capsular polysaccharide (CPS, K antigen); (b) siderophores responsible for binding ferric iron secreted by the hosts iron-binding proteins; and (c) adherence variables responsible for binding to host cell surfaces, such as fimbriae type 1 and type 3, and non-fimbrial adherence proteins. Ma L, Wang JT, Wu TL, Siu LK, Chuang YC, Lin JC, Lu MC, Lu PL. However, of 115 cases of K. pneumoniae meningitis reported in Taiwan, 84% were community acquired, and 64% of the cases had concurrent Klebsiella bacteremia [17]. Your US state privacy rights, Lee CR, Lee JH, Park KS, Jeon JH, Kim YB, Cha CJ, Jeong BC, Lee SH. Early identification and intervention are vital to reduce morbidity and prevent mortality due to this condition. The comprehensive Meta-analysis software version 3 was used to analyze the data. Many Klebsiella infections are acquired in the hospital setting or in long-term care facilities. Chin J Infect Chemother. Mechanisms of antimicrobial resistance are inactivation of compounds via enzymes, Although, imipenem and meropenem have shown good activity against Enterobacteriaceae [22], the situation observed in this review reiterates the public health implications of K. pneumoniae. pneumoniae is a well-known human nosocomial pathogen although it appears as the normal flora of the human oral cavity and intestine in most situations ( 1 ). Bacteriophage therapy against pathological Klebsiella pneumoniae Predictors of septic metastatic infection and mortality among patients with Klebsiella pneumoniae liver abscess. Klebsiella pneumoniae is a contagious bacteria that can cause infections such as pneumonia and sepsis. Klebsiella Infections Treatment & Management - Medscape Infections produced by Klebsiella pneumoniae are relatively rare, and hospital settings have the the highest prevalence of cases.

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